HSD17B8
Sign in to saveAlso known as D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1
Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.
In the Vinony graph
Within Vinony's link graph, HSD17B8 is referenced by 6 other articles, and connects out to PubMed, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 6.
Its subject is documented across 4 Wikipedia language editions.
Gene data
HSD17B8- Name
- hydroxysteroid 17-beta dehydrogenase 8
- Type
- protein-coding
- Position
- 33,204,631–33,206,831 (+)
- Aliases
- D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9
- Ensembl
- ENSG00000228712
- RefSeq RNA
- NM_014234.5
- RefSeq protein
- NP_055049.1
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
hydroxysteroid 17-beta dehydrogenase 8
- Symbol
- HSD17B8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:33,204,631-33,206,831
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HSD17B8 PDB 2pd6.png
Show 8 more facts
- HomoloGene ID
- 56588
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7923
- chromosome
- human chromosome 6
- genomic start
- 33204655
- genomic end
- 33174608
- cytogenetic location
- 6p21.32
- Commons category
- HSD17B8
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.
Excerpted from Wikipedia’s “HSD17B8” article, available under the CC BY-SA 4.0 licence.