PCDHB14

Name

protocadherin beta 14

Type

protein-coding

Aliases

PCDH-BETA14

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

protocadherin beta 14

Symbol

PCDHB14

Biotype

Protein coding

Organism

Homo sapiens

Location

5:141,223,343-141,227,759

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

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