PCDHB16
Sign in to saveAlso known as ME1, PCDH-BETA16, PCDH3X, PCDHB8a, protocadherin beta 16
Protocadherin beta-16 is a protein that in humans is encoded by the PCDHB16 gene.
Gene data
PCDHB16- Name
- protocadherin beta 16
- Type
- protein-coding
- Aliases
- ME1, PCDH-BETA16, PCDH3X, PCDHB8a
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
protocadherin beta 16
- Symbol
- PCDHB16
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:141,182,387-141,186,226
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 81881
- genomic start
- 141182387
- exact match
- identifiers.org/ncbigene/57717
- genomic end
- 141186226
- cytogenetic location
- 5q31.3
Sources (4)
via Wikidata · CC0
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Article
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- Further reading
Protocadherin beta-16 is a protein that in humans is encoded by the PCDHB16 gene.
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.