hydroflumethiazide

Also known as Saluron®, Hidroflumetiazid, Idroflumetiazide, Dihydroflumethazide, Hidroflumetiazida, Hydrofluméthiazide, Hydroflumethiazidum

Hydroflumethiazide (or Saluron) is a diuretic. == Synthesis == thumb|center|700px|Hydroflumethiazide synthesis: Numerous patents, e.g., Lund et al., (1966 to LEO Pharma|Lövens Kemiske Fabrik).

Chemical data

Formula: C8H8F3N3O4S2
Molecular weight: 331.3 g/mol
IUPAC name: 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
SMILES: C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1
InChIKey: DMDGGSIALPNSEE-UHFFFAOYSA-N
XLogP: 0.4
Polar surface area: 135 Å²
H-bond donors: 3
H-bond acceptors: 10
Formal charge: 0

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Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1959
Admin. routes: oral
Indications: cardiovascular disease

via ChEMBL · EBI

Research

198 papers

Hydroflumethiazide.2006
Hydroflumethiazide.The Practitioner · 1960
Hydrochlorothiazide & hydroflumethiazide.Postgraduate medical journal · 1960
The influence of polyvinylpyrrolidone on the dissolution properties of hydroflumethiazide.The Journal of pharmacy and pharmacology · 1975
Hydroflumethiazide as a diuretic.Journal of the Indian Medical Association · 1962

via PubMed

Wikidata facts

Subclass of: thiazide
Mass: 330.991
Has use: medication

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chemical formula: C₈H₈F₃N₃O₄S₂
medical condition treated: arterial hypertension
canonical SMILES: C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1
defined daily dose: 25
Commons category: Hydroflumethiazide

Sources (5)

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Encyclopedic overview

3 sections

Contents

Synthesis
See also
References

Hydroflumethiazide (or Saluron) is a diuretic. == Synthesis == thumb|center|700px|Hydroflumethiazide synthesis: Numerous patents, e.g., Lund et al., (1966 to LEO Pharma|Lövens Kemiske Fabrik).

== See also == Bendroflumethiazide

Excerpted from Wikipedia’s “hydroflumethiazide” article, available under the CC BY-SA 4.0 licence.

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