ibrexafungerp
Sign in to saveIbrexafungerp, sold under the brand name Brexafemme, is an antifungal medication used to treat vulvovaginal candidiasis (VVC) (vaginal yeast infection). It is taken orally (by mouth). It is also currently undergoing clinical trials for other indications via an intravenous (IV) formulation. An estimated 75% of women will have at least one episode of VVC and 40 to 45% will have two or more episodes in their lifetime.
Key facts
- Drug.tradename
- Brexafemme
- Drug.image
- Ibrexafungerp.svg
- Drug.image_class
- skin-invert-image
- Drug.DailyMedID
- Ibrexafungerp
- Drug.pregnancy_category
- Contraindicated
- Drug.routes_of_administration
- oral, intravenous
- Drug.class
- Antifungal
- Drug.ATC_prefix
- J02
- Drug.ATC_suffix
- AX07
- Drug.legal_US
- Rx-only
- Drug.protein_bound
- >99%
- Drug.metabolism
- Hydroxylation (CYP3A4) then conjugation (glucuronidation, sulfation)
- Drug.elimination_half life
- 20 hours
- Drug.index2_label
- as citrate
- Drug.CAS_number
- 1207753-03-4
- Drug.CAS_number2
- 1965291-08-0
- Drug.PubChem
- 46871657
- Drug.PubChem2
- 137552087
via Wikipedia infobox
Article
8 sectionsContents
- Medical uses
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Synthesis
- References
- Further reading
- External links
Ibrexafungerp, sold under the brand name Brexafemme, is an antifungal medication used to treat vulvovaginal candidiasis (VVC) (vaginal yeast infection). It is taken orally (by mouth). It is also currently undergoing clinical trials for other indications via an intravenous (IV) formulation. An estimated 75% of women will have at least one episode of VVC and 40 to 45% will have two or more episodes in their lifetime.
Ibrexafungerp acts via inhibition of glucan synthase, which prevents formation of the fungal cell wall.
Connections
Categories
4-Pyridyl compoundsAmino acidsAntifungalsChemical articles with multiple CAS registry numbersChemical articles with multiple PubChem CIDsChemical pages without ChemSpiderIDChemicals using indexlabelsHeterocyclic compounds with 5 ringsMultiple chemicals in Infobox drugOxygen heterocyclesSource attributionTert-butyl compounds