icatibant

Also known as HOE-140, HOE 140

Icatibant, sold under the brand name Firazyr, is a medication for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency. It is not effective in angioedema caused by medication from the ACE inhibitor class.

Research

1,542 papers

Is Icatibant Safe for the Treatment of Hereditary Angioedema During Pregnancy?Current allergy and asthma reports · 2022
Icatibant for hereditary angioedema.Drugs of today (Barcelona, Spain : 1998) · 2009
Icatibant in viral infections.Infectious diseases (London, England) · 2023
The Icatibant Outcome Survey: 10 years of experience with icatibant for patients with hereditary angioedema.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
Icatibant for the treatment of hereditary angioedema.The Annals of pharmacotherapy · 2013

via PubMed

Wikidata facts

Subclass of: chemical compound
Has part: carbon
Mass: 1303.661
Has use: medication

Show 5 more facts

chemical formula: C₅₉H₈₉N₁₉O₁₃S
World Health Organisation international non-proprietary name: icatibant
isomeric SMILES: C1CC[C@H]2[C@@H](C1)C[C@H](N2C(=O)[C@H]3CC4=CC=CC=C4CN3C(=O)[C@H](CO)NC(=O)[C@H](CC5=CC=CS5)NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H]7CCCN7C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)N)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
canonical SMILES: C1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O
defined daily dose: 30

Sources (3)

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