MRGPRX2

Also known as MGRG3, MRGX2, MAS related GPR family member X2

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.

In the Vinony graph

Within Vinony's link graph, MRGPRX2 is referenced by 493 other articles, and connects out to Q180686, Ensembl genome database project and cell surface receptor.

Vinony files it under Genes on human chromosome 11 and G protein-coupled receptors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MRGPRX2

Name: MAS related GPR family member X2
Type: protein-coding
Position: 19,054,455–19,060,717 (−)
Aliases: MGRG3, MRGX2
Ensembl: ENSG00000183695
RefSeq RNA: NM_001303615.2, NM_054030.4
RefSeq protein: NP_001290544.1, NP_473371.1

Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

via MyGene.info

Gene · Ensembl

MAS related GPR family member X2

Symbol: MRGPRX2
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:19,054,455-19,060,717
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 24986
exact match: identifiers.org/ncbigene/117194
genomic end: 19060717
genomic start: 19076002
cytogenetic location: 11p15.1

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Encyclopedic overview

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Contents

See also
References
Further reading

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.

Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity-like symptoms, also known as pseudoallergic reactions, although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome), icatibant, leuprolide, and morphine.

Excerpted from Wikipedia’s “MRGPRX2” article, available under the CC BY-SA 4.0 licence.