IFNB1

Name

interferon beta 1

Type

protein-coding

Position

21,077,104–21,077,942 (−)

Aliases

IFB, IFF, IFN-beta, IFNB

Ensembl

ENSG00000171855

RefSeq RNA

NM_002176.4

RefSeq protein

NP_002167.1

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015].

via MyGene.info

Wikidata facts

Image

Protein IFNB1 PDB 1au1.png

via Wikidata · CC0