IFNB1
Sign in to saveAlso known as IFB, IFF, IFNB, IFN-beta, interferon beta 1
Interferon beta is a protein that in humans is encoded by the IFNB1 gene. The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.
In the Vinony graph
Within Vinony's link graph, IFNB1 is referenced by 310 other articles, and connects out to interferon type I, PubMed and human chromosome 9.
It is catalogued under the topic Genes on human chromosome 9.
Its subject is documented across 6 Wikipedia language editions.
Gene data
IFNB1- Name
- interferon beta 1
- Type
- protein-coding
- Position
- 21,077,104–21,077,942 (−)
- Aliases
- IFB, IFF, IFN-beta, IFNB
- Ensembl
- ENSG00000171855
- RefSeq RNA
- NM_002176.4
- RefSeq protein
- NP_002167.1
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
interferon beta 1
- Symbol
- IFNB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:21,077,104-21,077,942
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein IFNB1 PDB 1au1.png
Show 7 more facts
- HomoloGene ID
- 1640
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3456
- genomic end
- 21077942
- genomic start
- 21077104
- chromosome
- human chromosome 9
- cytogenetic location
- 9p21.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Interferon beta is a protein that in humans is encoded by the IFNB1 gene. The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.
Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.
Excerpted from Wikipedia’s “IFNB1” article, available under the CC BY-SA 4.0 licence.