IFNK
Sign in to saveAlso known as IFNT1, INFE1, interferon kappa
Interferon kappa or IFN-kappa is a protein that in humans is encoded by the IFNK gene. Through different clinical studies, Interferon kappa has been assumed to play a role in controlling immune cell activity. It has been determined that this is a cytokine that gives cells species-specific resistance against viral infection. Interferon-stimulated response element signaling has also been hypothesized to be induced. This is because it has the ability to directly regulate the release of cytokines by monocytes and dendritic cells. It has also been discovered to bind heparin.
Gene data
IFNK- Name
- interferon kappa
- Type
- protein-coding
- Aliases
- IFNT1, INFE1
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
interferon kappa
- Symbol
- IFNK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:27,524,290-27,526,498
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 36384
- exact match
- identifiers.org/ncbigene/56832
- genomic start
- 27524290
- genomic end
- 27526496
- cytogenetic location
- 9p21.2
Sources (4)
via Wikidata · CC0
~10 min read
Article
7 sectionsContents
- Protein family
- Evolution and phylogeny
- Interactions
- Structure
- Clinical relevance
- References
- Further reading
Interferon kappa or IFN-kappa is a protein that in humans is encoded by the IFNK gene. Through different clinical studies, Interferon kappa has been assumed to play a role in controlling immune cell activity. It has been determined that this is a cytokine that gives cells species-specific resistance against viral infection. Interferon-stimulated response element signaling has also been hypothesized to be induced. This is because it has the ability to directly regulate the release of cytokines by monocytes and dendritic cells. It has also been discovered to bind heparin.
== Protein family == IFN-kappa belongs to the family of type I interferons. IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω are among the many cytokine subtypes that comprise the type I interferon family. A family of homologous glycoproteins known as type I interferons aids in the host's defense against viruses.