IGFALS
Sign in to saveAlso known as ALS, ACLSD, insulin like growth factor binding protein acid labile subunit
Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene.
In the Vinony graph
Vinony's link graph records 4 inbound references to IGFALS, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 16.
Vinony links it to 5 Wikipedia language editions.
Gene data
IGFALS- Name
- insulin like growth factor binding protein acid labile subunit
- Type
- protein-coding
- Position
- 1,790,227–1,794,971 (−)
- Aliases
- ACLSD, ALS
- Ensembl
- ENSG00000099769
- RefSeq RNA
- NM_001146006.2, NM_004970.3, NR_027389.1
- RefSeq protein
- NP_001139478.1, NP_004961.1
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
insulin like growth factor binding protein acid labile subunit
- Symbol
- IGFALS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:1,790,227-1,794,971
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 37987
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3483
- genomic end
- 1844972
- genomic start
- 1840414
- chromosome
- human chromosome 16
- cytogenetic location
- 16p13.3
- expressed in
- middle temporal gyrus
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene.
== Function ==
Excerpted from Wikipedia’s “IGFALS” article, available under the CC BY-SA 4.0 licence.