IKBKB
Sign in to saveAlso known as IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta, IMD15A
IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.
Gene data
IKBKB- Name
- inhibitor of nuclear factor kappa B kinase subunit beta
- Type
- protein-coding
- Position
- 42,271,302–42,332,460 (+)
- Aliases
- IKK-2, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB
- Ensembl
- ENSG00000104365
- RefSeq RNA
- NM_001190720.3, NM_001190721.1, NM_001190722.1, NM_001242778.2, NM_001556.3
- RefSeq protein
- NP_001177649.2, NP_001229707.1, NP_001547.1, XP_011542819.1, XP_011542822.1
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
inhibitor of nuclear factor kappa B kinase subunit beta
- Symbol
- IKBKB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:42,271,302-42,332,460
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- See also
IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.
== Function ==
Excerpted from Wikipedia’s “IKBKB” article, available under the CC BY-SA 4.0 licence.