IL12RB1

Name

interleukin 12 receptor subunit beta 1

Type

protein-coding

Aliases

CD212, IL-12R-BETA1, IL12RB, IMD30

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].

via MyGene.info

Gene · Ensembl

interleukin 12 receptor subunit beta 1

Symbol

IL12RB1

Biotype

Protein coding

Organism

Homo sapiens

Location

19:18,058,995-18,098,944

Strand

Reverse (−)

Assembly

GRCh38