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imidazenil
Sign in to saveImidazenil is an experimental anxiolytic drug which is derived from the benzodiazepine family, and is most closely related to other imidazobenzodiazepines such as midazolam, flumazenil, and bretazenil.
Chemical data
- Formula
- C18H12BrFN4O
- Molecular weight
- 399.2 g/mol
- IUPAC name
- 6-(2-bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide
- SMILES
- C1C2=C(N=CN2C3=C(C=C(C=C3)F)C(=N1)C4=CC=CC=C4Br)C(=O)N
- InChIKey
- OCJHYHKWUWSHEN-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 73.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
58 papers- Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.The Journal of pharmacology and experimental therapeutics · 1993
- Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation.Proceedings of the National Academy of Sciences of the United States of America · 2006
- Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.Neuropharmacology · 2008
- Neuroprotective effects of imidazenil against chemical warfare nerve agent soman toxicity in guinea pigs.Neurotoxicology · 2012
- Imidazenil, a new partial agonist of benzodiazepine receptors, reverses the inhibitory action of isoniazid and stress on gamma-aminobutyric acidA receptor function.The Journal of pharmacology and experimental therapeutics · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 398.018
Show 3 more facts
- chemical formula
- C₁₈H₁₂BrFN₄O
- canonical SMILES
- C1C2=C(N=CN2C3=C(C=C(C=C3)F)C(=N1)C4=CC=CC=C4Br)C(=O)N
- Commons category
- Imidazenil
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Pharmacodynamics
- See also
- References
Imidazenil is an experimental anxiolytic drug which is derived from the benzodiazepine family, and is most closely related to other imidazobenzodiazepines such as midazolam, flumazenil, and bretazenil.
Imidazenil is a highly potent benzodiazepine receptor partial agonist with an unusual profile of effects, producing some of the effects associated with normal benzodiazepines such as anticonvulsant and anxiolytic effects, yet without any notable sedative or amnestic effects. In fact, imidazenil blocks the sedative effects of diazepam, yet without lowering the convulsion threshold, and so potentially could be a more flexible antidote than the antagonist flumazenil which is commonly used to treat benzodiazepine overdose at present.
Excerpted from Wikipedia’s “imidazenil” article, available under the CC BY-SA 4.0 licence.