Interleukin 3 receptor subunit alpha

Protein · UniProt

Interleukin-3 receptor subunit alpha

Gene

IL3RA

Organism

Homo sapiens (Human)

Length

378 aa

Molecular mass

43,330 Da

Evidence

1: Evidence at protein level

Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity)

• Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm.The New England journal of medicine · 2019
• Interleukin-3 receptor in acute leukemia.Leukemia · 2004
• A γδ T cell-IL-3 axis controls allergic responses through sensory neurons.Nature · 2024
• CD123 (interleukin 3 receptor alpha chain).Journal of biological regulators and homeostatic agents · 2001
• Conformational and binding mode assessment of the human IL-3 recognition by its alpha receptor.Proteins · 2023

via PubMed

• PHASE2WITHDRAWN
  Flotetuzumab in Treating Patients With Recurrent or Refractory CD123 Positive Blood CancerCity of Hope Medical Center · NCT03739606
• PHASE1ACTIVE_NOT_RECRUITING
  Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell NeoplasmCity of Hope Medical Center · NCT02159495

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Image

CD123.png

via Wikidata · CC0