Structure via PubChem · Public domain (PubChem)
iotrolan
Sign in to saveAlso known as Iotrolum, Iotrolanum
Iotrolan (trade name Isovist) is an iodine-containing radiocontrast agent, a substance used to improve the visibility of body structures on images obtained by X-ray techniques.
Chemical data
- Formula
- C37H48I6N6O18
- Molecular weight
- 1626.2 g/mol
- IUPAC name
- 2,4,6-triiodo-5-[methyl-[3-oxo-3-[2,4,6-triiodo-N-methyl-3,5-bis(1,3,4-trihydroxybutan-2-ylcarbamoyl)anilino]propanoyl]amino]-1-N,3-N-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide
- SMILES
- CN(C1=C(C(=C(C(=C1I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I)C(=O)CC(=O)N(C)C2=C(C(=C(C(=C2I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I
- InChIKey
- XUHXFSYUBXNTHU-UHFFFAOYSA-N
- XLogP
- -4.2
- Polar surface area
- 400 Ų
- H-bond donors
- 16
- H-bond acceptors
- 18
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Unknown
- First approval
- 1989
- Admin. routes
- parenteral
via ChEMBL · EBI
Research
289 papers- [The new nonionic contrast preparation for myelography iotrolan].Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko · 1994
- Iotrolan versus iopamidol: a controlled, multicenter, double-blind study of lumbar and direct cervical myelography.Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband · 1989
- The lack of immunogenicity of iotrolan.Investigative radiology · 1995
- Safety and pharmacokinetics of iotrolan in hysterosalpingography. Retention and irritability compared with Lipiodol.Investigative radiology · 1995
- Aseptic meningitis complicating iotrolan myelography.AJNR. American journal of neuroradiology · 1991
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 1625.729
Show 3 more facts
- chemical formula
- C₃₇H₄₈I₆N₆O₁₈
- canonical SMILES
- CN(C1=C(C(=C(C(=C1I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I)C(=O)CC(=O)N(C)C2=C(C(=C(C(=C2I)C(=O)NC(CO)C(CO)O)I)C(=O)NC(CO)C(CO)O)I
- subject has role
- contrast agent
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Interactions
- Chemistry and mechanism of action
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 407439119 | IUPAC_name = 2,4,6-triiodo-5-{N-methyl-2-[methyl({2,4,6-triiodo-3,5-bis[(1,3,4-trihydroxybutan-2-yl)carbamoyl]phenyl})carbamoyl]acetamido}-1-N,3-N-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide | image = Iotrolan.png | image_class = skin-invert-image | width = 300
| tradename = Isovist | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = Contraindicated | legal_AU = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration =
Excerpted from Wikipedia’s “iotrolan” article, available under the CC BY-SA 4.0 licence.