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JM-1232
Sign in to saveJM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. It was developed by a team at Maruishi Pharmaceutica.
Chemical data
- Formula
- C24H27N3O2
- Molecular weight
- 389.5 g/mol
- IUPAC name
- (3R)-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-2-phenyl-3,5,6,7-tetrahydrocyclopenta[f]isoindol-1-one
- SMILES
- CN1CCN(CC1)C(=O)C[C@@H]2C3=C(C=C4CCCC4=C3)C(=O)N2C5=CC=CC=C5
- InChIKey
- MBGOHVUPIPFVMM-JOCHJYFZSA-N
- XLogP
- 2.6
- Polar surface area
- 43.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 389.210327
Show 4 more facts
- chemical formula
- C₂₄H₂₇N₃O₂
- canonical SMILES
- CN1CCN(CC1)C(=O)CC2C3=CC4=C(CCC4)C=C3C(=O)N2C5=CC=CC=C5
- isomeric SMILES
- CN1CCN(CC1)C(=O)C[C@@H]2C3=CC4=C(CCC4)C=C3C(=O)N2C5=CC=CC=C5
- Commons category
- JM-1232
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. It was developed by a team at Maruishi Pharmaceutica.
A human study explored the sedation caused by infusions at a range of doses, finding a fair hemodynamic safety profile.
Excerpted from Wikipedia’s “JM-1232” article, available under the CC BY-SA 4.0 licence.