Kallidin belongs to the family kinins, which are the peptide hormones. Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. Removal of the N-terminal lysine by Factor XII, or to a leser extent aminopeptidase yields the potently bioactive bradykinin molecule.
via PubMed
Kallidin belongs to the family kinins, which are the peptide hormones. Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. Removal of the N-terminal lysine by Factor XII, or to a leser extent aminopeptidase yields the potently bioactive bradykinin molecule.
== Formation of Kinins == In the early 1940s, researcher Eugen Werle worked extensively with his colleague Fritz Fiedler to study enzymes like kallikrein and their biological activation and inhibition behavior at different pH. Their research defined the properties and chemical actions of kallikrein, an enzyme in the kinin-kallikrein system that is connected to the body's cardiovascular, renal and inflammatory systems.
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