Structure via PubChem · Public domain (PubChem)
kallidin
Sign in to saveKallidin belongs to the family kinins, which are the peptide hormones. Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. Removal of the N-terminal lysine by Factor XII, or to a leser extent aminopeptidase yields the potently bioactive bradykinin molecule.
In the Vinony graph
Vinony's link graph records 26 inbound references to kallidin, and connects out to International Standard Book Number, digital object identifier and International Standard Serial Number.
It is catalogued under topics including Chembox image size set, Decapeptides and ECHA InfoCard ID from Wikidata.
Vinony links it to 17 Wikipedia language editions.
Chemical data
- Formula
- C56H85N17O12
- Molecular weight
- 1188.4 g/mol
- IUPAC name
- (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
- SMILES
- C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
- InChIKey
- FYSKZKQBTVLYEQ-FSLKYBNLSA-N
- XLogP
- -5.3
- Polar surface area
- 474 Ų
- H-bond donors
- 14
- H-bond acceptors
- 16
- Formal charge
- 0
via PubChem
Research
777 papers- Hypotensive peptides: bradykinin, kallidin, and eledoisin.Advances in pharmacology · 1966
- [Biochemistry of bradykinin and kallidin].Seikagaku. The Journal of Japanese Biochemical Society · 1967
- Bradykinin, kallidin, and their synthetic analogues.Experientia · 1964
- Receptors for bradykinin and kallidin.Canadian journal of physiology and pharmacology · 1979
- [Kallidin and bradykinin].Archives internationales de pharmacodynamie et de therapie · 1953
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 1187.656361
Show 4 more facts
- chemical formula
- C₅₆H₈₅N₁₇O₁₂
- canonical SMILES
- C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCN=C(N)N)C(=O)O
- isomeric SMILES
- C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
- subject has role
- vasodilator agent
Sources (3)
via Wikidata · CC0
~5 min read
Encyclopedic overview
6 sectionsContents
- Formation of Kinins
- Effects of Kinins and Its Role in Disease
- Chemical Mechanisms
- Clarification
- See also
- References
Kallidin belongs to the family kinins, which are the peptide hormones. Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. Removal of the N-terminal lysine by Factor XII, or to a leser extent aminopeptidase yields the potently bioactive bradykinin molecule.
== Formation of Kinins == In the early 1940s, researcher Eugen Werle worked extensively with his colleague Fritz Fiedler to study enzymes like kallikrein and their biological activation and inhibition behavior at different pH. Their research defined the properties and chemical actions of kallikrein, an enzyme in the kinin-kallikrein system that is connected to the body's cardiovascular, renal and inflammatory systems.
Excerpted from Wikipedia’s “kallidin” article, available under the CC BY-SA 4.0 licence.