autacoids
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Autacoids or autocoids are biological factors (molecules) which act like local hormones, have a brief duration, and act near their site of biosynthesis. The word autacoid comes from the Greek words "autos" (self) and "acos" (relief; i.e., drug). The effects of autacoids are primarily local, though large quantities can be produced and moved into circulation. Autacoids may thus have systemic effects by being transported via the circulation. These regulating molecules are also metabolized locally. In sum, these compounds typically are produced locally, act locally and are metabolized locally. Aut
Research
306,948 papers- Resolution-promoting autacoids demonstrate promising cardioprotective effects against heart diseases.Molecular biology reports · 2022
- Autacoids and control of human placental blood flow.Clinical and experimental pharmacology & physiology · 1994
- Autacoids as modulators of the inflammatory and immune response.The American journal of medicine · 1981
- Autacoids affecting vascular tone in the human fetal extracorporeal circulation.Clinical and experimental pharmacology & physiology · 1992
- Resolvins and aliamides: lipid autacoids in ophthalmology - what promise do they hold?Drug design, development and therapy · 2016
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Autacoids or autocoids are biological factors (molecules) which act like local hormones, have a brief duration, and act near their site of biosynthesis. The word autacoid comes from the Greek words "autos" (self) and "acos" (relief; i.e., drug). The effects of autacoids are primarily local, though large quantities can be produced and moved into circulation. Autacoids may thus have systemic effects by being transported via the circulation. These regulating molecules are also metabolized locally. In sum, these compounds typically are produced locally, act locally and are metabolized locally. Autacoids can have a variety of different biological actions, including modulating the activities of smooth muscles, glands, nerves, platelets and other tissues.
Some autacoids are chiefly characterized by the effect they have on specific tissues, such as smooth muscle. With respect to vascular smooth muscle, there exist both vasoconstrictor and vasodilator autacoids. Vasodilator autacoids are released during periods of exercise. Their main effect is seen in the skin, where they facilitate heat loss.
Excerpted from Wikipedia’s “autacoids” article, available under the CC BY-SA 4.0 licence.