kallikreins
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (encoded by KLKB1 gene) has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.
Research
46,131 papers- The role of kallikreins in inflammatory skin disorders and their potential as therapeutic targets.Critical reviews in clinical laboratory sciences · 2021
- Kallikreins and kinins in inflammatory-like events in the reproductive tract.Pharmacological research · 1997
- Kallikreins and lupus nephritis.The Journal of clinical investigation · 2009
- Kallikrein-related peptidases.Cellular and molecular life sciences : CMLS · 2008
- Kallikreins are involved in an miRNA network that contributes to prostate cancer progression.Biological chemistry · 2014
via PubMed
Article
11 sectionsContents
- Occurrence
- Venom
- Plasma kallikrein
- Structure
- Tissue kallikreins
- Function
- Genes
- Clinical significance
- See also
- References
- External links
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (encoded by KLKB1 gene) has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.
==Occurrence==