KIT ligand

Protein · UniProt

Kit ligand

Gene

KITLG

Organism

Homo sapiens (Human)

Length

273 aa

Molecular mass

30,899 Da

Evidence

1: Evidence at protein level

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and …

• PHASE1COMPLETED
  Stem Cell Factor Medication for Aplastic AnemiaNational Heart, Lung, and Blood Institute (NHLBI) · NCT00001398
• PHASE2COMPLETED
  Comparing Treatments for Multiple MyelomaNational Heart, Lung, and Blood Institute (NHLBI) · NCT00001750
• PHASE1COMPLETED
  A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling DisordersNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT00005783
• EARLY_PHASE1UNKNOWN
  Lenalidomide and Recombinant Human Stem Cell Factor for Treatment of MyelodysplasiaPeter MacCallum Cancer Centre, Australia · NCT00434239
• COMPLETED
  Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy IndividualsNational Institute of Allergy and Infectious Diseases (NIAID) · NCT00001760
• COMPLETED
  Characteristics of Mast Cells in MastocytosisNational Institute of Allergy and Infectious Diseases (NIAID) · NCT00001356

via ClinicalTrials.gov

Wikidata facts

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protein

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