lamivudine/zidovudine

Also known as lamivudine / zidovudine, Combivir

Lamivudine/zidovudine, sold under the brand name Combivir among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. It contains two antiretroviral medications, lamivudine and zidovudine. It is used together with other antiretrovirals. It is taken by mouth twice a day.

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chemical formula: C₁₈H₂₄N₈O₇S
canonical SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-].C1C(OC(S1)CO)N2C=CC(=NC2=O)N
isomeric SMILES: Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)nc1O.N=c1ccn([C@@H]2CS[C@H](CO)O2)c(O)n1

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Article

12 sections

Contents

Medical uses
Pregnancy
Side effects
Interactions
Drug-drug interactions
Drug-food interactions
Mechanism of action
Pharmacokinetics
History
Society and culture
Drug formulations
References

Common side effects include headache, feeling tired, nausea, diarrhea, and fever. Severe side effects may include bone marrow suppression, muscle damage, worsening of hepatitis B if previously infected, high blood lactate and liver enlargement. It may be part of a recommended treatment during pregnancy. The medications are both of the nucleoside reverse transcriptase inhibitor (NRTI) class. They work by blocking the action of the enzyme, reverse transcriptase, that the virus requires to reproduce.