Also known as BPIFD2, lipopolysaccharide binding protein
gen de la especie Homo sapiens
Gene data
LBP- Name
- lipopolysaccharide binding protein
- Type
- protein-coding
- Position
- 38,346,076–38,378,131 (+)
- Aliases
- BPIFD2
- Ensembl
- ENSG00000129988
- RefSeq RNA
- NM_004139.5
- RefSeq protein
- NP_004130.2
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
lipopolysaccharide binding protein
- Symbol
- LBP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:38,346,076-38,378,131
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- LBP protein.png
Show 8 more facts
- HomoloGene ID
- 3055
- genetic association
- periodontitis
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3929
- genomic end
- 38377013
- genomic start
- 38346482
- chromosome
- human chromosome 20
- cytogenetic location
- 20q11.23
Sources (8)
via Wikidata · CC0