TLR5

Name

toll like receptor 5

Type

protein-coding

Position

223,108,387–223,143,318 (−)

Aliases

MELIOS, SLE1, SLEB1, TIL3

Ensembl

ENSG00000187554

RefSeq RNA

NM_001437539.1, NM_001437624.1, NM_001437650.1, NM_001437651.1, NM_003268.6

RefSeq protein

NP_001424468.1, NP_001424553.1, NP_001424579.1, NP_001424580.1, NP_003259.2

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009].

via MyGene.info

Gene · Ensembl

toll like receptor 5

Symbol

TLR5

Biotype

Protein coding

Organism

Homo sapiens

Location

1:223,108,387-223,143,318

Strand

Reverse (−)

Assembly

GRCh38