LEFTY2

Name

left-right determination factor 2

Type

protein-coding

Position

225,936,598–225,941,532 (−)

Aliases

EBAF, LEFTA, LEFTYA, TGFB4

Ensembl

ENSG00000143768

RefSeq RNA

NM_001172425.3, NM_003240.5, XM_011544266.2, XM_054338528.1

RefSeq protein

NP_001165896.1, NP_003231.2, XP_011542568.1, XP_054194503.1

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].

via MyGene.info

Gene · Ensembl

left-right determination factor 2

Symbol

LEFTY2

Biotype

Protein coding

Organism

Homo sapiens

Location

1:225,936,598-225,941,532

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

via Wikidata · CC0