File:Losartan_structure.svg · Wikimedia Commons · See Wikimedia Commons
Losartan
Sign in to saveAlso known as DuP 753, MK-954, 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole, (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol, DuP 89
sartano di indicazione specifica contro l'ipertensione arteriosa e l'insufficienza cardiaca
OverviewAI-generated
Losartan is a chemical compound with the formula C₂₂H₂₃ClN₆O. It has a mass of 422.162 and a weight of 422.9. The defined daily dose for this substance is 50. Its canonical SMILES notation is CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl.
Chemical properties of losartan include an xlogp value of 4.3 and a topological polar surface area of 92.5. The molecule contains two hydrogen bond donors and five hydrogen bond acceptors, with a charge of 0. The InChIKey for the compound is PSIFNNKUMBGKDQ-UHFFFAOYSA-N.
Losartan is associated with a PubMed query count of 11351. It is referenced by 268 other encyclopedia articles. A Commons category exists for the subject.
Synthesized by Vinony from 17 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.verifiedrevid
- 458612349
- Drug.image
- Losartan structure.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula
- Drug.width
- 200
- Drug.image2
- Losartan-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model
- Drug.tradename
- Cozaar, others
- Drug.MedlinePlus
- a695008
- Drug.DailyMedID
- Losartan
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Angiotensin II receptor antagonist
- Drug.ATC_prefix
- C09
- Drug.ATC_suffix
- CA01
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C22H23ClN6O
- Molecular weight
- 422.9 g/mol
- IUPAC name
- [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
- SMILES
- CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
- InChIKey
- PSIFNNKUMBGKDQ-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 92.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1995
- Admin. routes
- oral
- Indications
- cardiovascular disease, diabetic nephropathy, glioblastoma multiforme, hypertension
via ChEMBL · EBI
Research
11,351 papers- Clinical pharmacokinetics of losartan.Clinical pharmacokinetics · 2005
- Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
- Hyperuricemia and Gout: The Role of Losartan.The Senior care pharmacist · 2023
- Topical Losartan in the Management of Corneal Scarring Fibrosis: Update on Dosage, Efficacy, and Potential Epithelial Toxicity.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2025
- Topical Losartan in the Treatment of Stromal Scarring After Refractive Surgery.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2025
via PubMed
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- nitrogen
- Mass
- 422.162
- Has use
- medication
Show 9 more facts
- chemical formula
- C₂₂H₂₃ClN₆O
- subject has role
- essential medicine
- Commons category
- Losartan
- medical condition treated
- arterial hypertension
- canonical SMILES
- CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
- defined daily dose
- 50
- World Health Organisation international non-proprietary name
- losartan
- legal status (medicine)
- boxed warning
- significant drug interaction
- perindopril
Sources (6)
via Wikidata · CC0
Article · Italiano
Il Losartan potassico è un sartano di indicazione specifica contro l'ipertensione arteriosa e l'insufficienza cardiaca. Nomi commerciali in Italia: Lortaan (MSD); Losaprex (Sigma-tau); Neolotan (Neopharmed).
Abstract from DBpedia / Wikipedia · CC BY-SA