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GeneQ6459655· pop 5· linked from 487 articles

LPAR2

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Also known as EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2

Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene. LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Gene data

LPAR2
Name
lysophosphatidic acid receptor 2
Type
protein-coding
Position
19,623,639–19,628,930 (−)
Aliases
EDG-4, EDG4, LPA-2, LPA2
Ensembl
ENSG00000064547
RefSeq RNA
NM_001395660.1, NM_004720.7
RefSeq protein
NP_001382589.1

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Rap1 signaling pathway - Homo sapiens (human)Phospholipase D signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)Pathogenic Escherichia coli infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)

via MyGene.info

Gene · Ensembl

lysophosphatidic acid receptor 2

Symbol
LPAR2
Biotype
Protein coding
Organism
Homo sapiens
Location
19:19,623,639-19,628,930
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

8 sections
Contents
  • Function
  • Interactions
  • Evolution
  • [[Sequence homology|Paralogues]]
  • See also
  • References
  • Further reading
  • External links

Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene. LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

== Function == This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.

Excerpted from Wikipedia’s “LPAR2” article, available under the CC BY-SA 4.0 licence.

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