Lysostaphin
Sign in to saveAlso known as Glycyl-glycine endopeptidase
thumb | right Lysostaphin (, glycyl-glycine endopeptidase) is a Staphylococcus simulans metalloendopeptidase (crystal structure of lysostaphin). It can function as a bacteriocin (antimicrobial) against Staphylococcus aureus.
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Vinony's link graph records 149 inbound references to Lysostaphin, and connects out to Q180686, Staphylococcus aureus and Q229883.
It is catalogued under topics including Antimicrobial peptides, Bacterial toxins and Bactericides.
Vinony links it to 6 Wikipedia language editions.
Wikidata facts
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- EC enzyme number
- 3.4.24.75
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thumb | right Lysostaphin (, glycyl-glycine endopeptidase) is a Staphylococcus simulans metalloendopeptidase (crystal structure of lysostaphin). It can function as a bacteriocin (antimicrobial) against Staphylococcus aureus.
Lysostaphin is a 27 KDa glycylglycine endopeptidase, an antibacterial enzyme which is capable of cleaving the crosslinking pentaglycine bridges found in the cell wall peptidoglycan of certain staphylococci. Lysostaphin was first isolated from a culture of Staphylococcus simulans by Schindler and Schuhardt in 1964. S. aureus cell walls contain high proportions of pentaglycine, making lysostaphin a highly effective agent against both actively growing and quiescent bacteria.
Excerpted from Wikipedia’s “Lysostaphin” article, available under the CC BY-SA 4.0 licence.