MAPK1

Name

mitogen-activated protein kinase 1

Type

protein-coding

Position

21,755,537–21,867,680 (−)

Aliases

ERK, ERK-2, ERK2, ERT1, MAPK2, NS13, P42MAPK, PRKM1, PRKM2, p38

Ensembl

ENSG00000100030

RefSeq RNA

NM_002745.5, NM_138957.3

RefSeq protein

NP_002736.3, NP_620407.1

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].

via MyGene.info

Gene · Ensembl

mitogen-activated protein kinase 1

Symbol

MAPK1

Biotype

Protein coding

Organism

Homo sapiens

Location

22:21,755,537-21,867,680

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein MAPK1 PDB 1erk.png

via Wikidata · CC0