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medazepam
Sign in to saveMedazepam is a drug that is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It is known by the following brand names: Azepamid, Nobrium, Tranquirax (mixed with bevonium), Rudotel, Raporan, Ansilan and Mezapam. Medazepam is a long-acting benzodiazepine drug. The half-life of medazepam is 36–200 hours.
Chemical data
- Formula
- C16H15ClN2
- Molecular weight
- 270.75 g/mol
- IUPAC name
- 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine
- SMILES
- CN1CCN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
- InChIKey
- YLCXGBZIZBEVPZ-UHFFFAOYSA-N
- XLogP
- 4.4
- Polar surface area
- 15.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
257 papers- [Medazepam].Vnitrni lekarstvi · 1970
- PKa for medazepam.Journal of pharmaceutical sciences · 1976
- Acute kidney injury with medazepam-hyoscine buthylbromide.Wiener klinische Wochenschrift · 2014
- A study of the effects of large doses of medazepam used for self-poisoning in 10 pregnant women on fetal development.Toxicology and industrial health · 2008
- Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.Toxicology letters · 2010
via PubMed
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Encyclopedic overview
4 sectionsContents
- Pharmacology
- See also
- References
- External links
Medazepam is a drug that is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It is known by the following brand names: Azepamid, Nobrium, Tranquirax (mixed with bevonium), Rudotel, Raporan, Ansilan and Mezapam. Medazepam is a long-acting benzodiazepine drug. The half-life of medazepam is 36–200 hours.
==Pharmacology== Medazepam acts as a prodrug to nordazepam. Benzodiazepine drugs including medazepam increase the inhibitory processes in the cerebral cortex by allosteric modulation of the GABA receptor. Benzodiazepines may also act via micromolar benzodiazepine-binding sites as Ca2+ channel blockers and significantly inhibited depolarization-sensitive calcium uptake in experiments with cell components from rat brains. This has been conjectured as a mechanism for high dose effects against seizures in a study. It has major active benzodiazepine metabolites, which gives it a more prolonged therapeutic effect after administration.
Excerpted from Wikipedia’s “medazepam” article, available under the CC BY-SA 4.0 licence.