MEP1B
Sign in to saveAlso known as meprin A subunit beta
Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.
In the Vinony graph
Vinony's link graph records 8 inbound references to MEP1B, and connects out to PubMed, human chromosome 18 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 18.
Vinony links it to 5 Wikipedia language editions.
Gene data
MEP1B- Name
- meprin A subunit beta
- Type
- protein-coding
- Position
- 32,185,069–32,222,605 (+)
- Ensembl
- ENSG00000141434
- RefSeq RNA
- NM_001308171.2, NM_005925.3, XM_011526013.3, XM_011526014.3, XM_054318658.1
- RefSeq protein
- NP_001295100.1, NP_005916.2, XP_011524315.1, XP_011524316.1, XP_054174633.1
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
meprin A subunit beta
- Symbol
- MEP1B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:32,185,069-32,222,605
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 48382
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4225
- chromosome
- human chromosome 18
- genomic end
- 29800367
- genomic start
- 29765032
- cytogenetic location
- 18q12.1
- expressed in
- smooth muscle tissue
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha (MEP1A; MIM 600388) are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Substrates include bioactive peptides and extracellular matrix proteins. See MIM 600388 for further information on meprins.[supplied by OMIM]
Excerpted from Wikipedia’s “MEP1B” article, available under the CC BY-SA 4.0 licence.