PPP1R1B
Sign in to saveAlso known as DARPP-32, DARPP32, protein phosphatase 1 regulatory inhibitor subunit 1B
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.
Gene data
PPP1R1B- Name
- protein phosphatase 1 regulatory inhibitor subunit 1B
- Type
- protein-coding
- Position
- 39,626,740–39,636,626 (+)
- Aliases
- DARPP-32, DARPP32
- Ensembl
- ENSG00000131771
- RefSeq RNA
- NM_001242464.2, NM_032192.4, NM_181505.4, XM_017025216.3, XM_017025217.3
- RefSeq protein
- NP_001229393.1, NP_115568.2, NP_852606.1, XP_016880705.1, XP_016880706.1
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
protein phosphatase 1 regulatory inhibitor subunit 1B
- Symbol
- PPP1R1B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:39,626,740-39,636,626
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
9 sectionsContents
- Function
- Clinical significance
- CNS
- Cancer
- Regulation
- Discovery
- Interactive pathway map
- References
- Further reading
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.
== Function ==
Excerpted from Wikipedia’s “PPP1R1B” article, available under the CC BY-SA 4.0 licence.