metitepine
Sign in to saveMetitepine (; developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic or tetracyclic group which was never marketed.
Key facts
- Drug.IUPAC_name
- 1-methyl-4-(8-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)piperazine
- Drug.image
- Metitepine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 225px
- Drug.CAS_number
- 20229-30-5
- Drug.CAS_supplemental
- 19728-88-2 (maleate)
- Drug.PubChem
- 4106
- Drug.IUPHAR_ligand
- 89
- Drug.ChemSpiderID
- 3963
- Drug.ChEBI
- 64203
- Drug.UNII
- 55D94103HL
- Drug.synonyms
- Methiothepin; Methiothepine; Ro 8-6837 (maleate); VUFB-6276 (mesylate)
- Drug.C
- 20
- Drug.H
- 24
- Drug.N
- 2
- Drug.S
- 2
- Drug.SMILES
- CN1CCN(CC1)C2Cc3ccccc3Sc4c2cc(cc4)SC
- Drug.StdInChI
- 1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
via Wikipedia infobox
Research
1,049 papers- Structure of a Hallucinogen-Activated Gq-Coupled 5-HT(2A) Serotonin Receptor.Cell · 2020
- Metitepine distinguishes two receptors mediating inhibition of [3H]-5-hydroxytryptamine release in guinea pig hippocampus.Naunyn-Schmiedeberg's archives of pharmacology · 1992
- Stereoselective actions of the isomers of metitepine at 5-HT1D receptors in the guinea pig brain.Neuropharmacology · 1993
- Serotonin and vascular reactivity.Pharmacological research communications · 1985
- Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target.Scientific reports · 2013
via PubMed
Article
7 sectionsContents
- Pharmacology
- Pharmacodynamics
- Chemistry
- Analogues
- Synthesis
- References
- External links
Metitepine (; developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic or tetracyclic group which was never marketed.
It acts as a non-selective antagonist of serotonin, dopamine, and adrenergic receptors, including of the serotonin 5-HT1, 5-HT2, 5-HT5, 5-HT6, and 5-HT7 receptors. The drug has antipsychotic properties.