Structure via PubChem · Public domain (PubChem)
profenamine
Sign in to saveAlso known as Parsidol®, N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine, 10-[2-(diethylamino)-2-methylethyl]phenothiazine, N,N-diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine, 10-[2-(diethylamino)-1-propyl]phenothiazine, 10-[2-(diethylamino)propyl]phenothiazine, ethopropazine, 10-(2-diethylaminopropyl)phenothiazine
Profenamine (INN; also known as ethopropazine (BAN); sold under the trade name Parsidol and others) is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.
Chemical data
- Formula
- C19H24N2S
- Molecular weight
- 312.5 g/mol
- IUPAC name
- N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
- Indications
- Parkinson disease
via ChEMBL · EBI
Research
48 papers- Comparison of the stimulatory effects of eight antiparkinsonian drugs.Progress in neuro-psychopharmacology & biological psychiatry · 1984
- Dopamine alleviates cadmium stress in apple trees by recruiting beneficial microorganisms to enhance the physiological resilience revealed by high-throughput sequencing and soil metabolomics.Horticulture research · 2023
- Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2007
- N-substituted phenothiazines as redox indicators in titrations with chloramine-T and chloramine-B.Talanta · 1980
- Butyrylcholinesterase and cognitive function.International psychogeriatrics · 2001
via PubMed
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Profenamine (INN; also known as ethopropazine (BAN); sold under the trade name Parsidol and others) is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.
==Synthesis== For promoting bone growth:
Excerpted from Wikipedia’s “profenamine” article, available under the CC BY-SA 4.0 licence.