Structure via PubChem · Public domain (PubChem)
mitapivat
Sign in to saveAlso known as PKR-IN-1, Pyrukynd, AG-348
Mitapivat, sold under the brand name Pyrukynd among others, is a medication used to treat different types of anemia. It is taken as the sulfate hydrate salt by mouth. Mitapivat is a pyruvate kinase activator.
Chemical data
- Formula
- C24H26N4O3S
- Molecular weight
- 450.6 g/mol
- IUPAC name
- N-[4-[4-(cyclopropylmethyl)piperazine-1-carbonyl]phenyl]quinoline-8-sulfonamide
- SMILES
- C1CC1CN2CCN(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC5=C4N=CC=C5
- InChIKey
- XAYGBKHKBBXDAK-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 91 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2022
- Admin. routes
- oral
- Indications
- Thalassemia, sickle cell anemia, Alpha-thalassemia, Beta-thalassemia
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 450.172561692
- Has use
- medication
Show 2 more facts
- canonical SMILES
- C1CC1CN2CCN(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC5=C4N=CC=C5
- chemical formula
- C₂₄H₂₆N₄O₃S
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Pharmacology
- Mechanism of action
- History
- Society and culture
- Legal status
- Names
- References
- Further reading
- External links
Mitapivat, sold under the brand name Pyrukynd among others, is a medication used to treat different types of anemia. It is taken as the sulfate hydrate salt by mouth. Mitapivat is a pyruvate kinase activator.
The most common side effects include decreases in estrone and estradiol (types of the estrogen hormone) in men, increased urate (a type of salt in the body), back pain, and joint stiffness.
Excerpted from Wikipedia’s “mitapivat” article, available under the CC BY-SA 4.0 licence.