Structure via PubChem · Public domain (PubChem)
ranimustine
Sign in to saveRanimustine (INN, marketed under the tradename Cymerin; also known as MCNU) is a nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia and polycythemia vera.
Chemical data
- Formula
- C10H18ClN3O7
- Molecular weight
- 327.72 g/mol
- IUPAC name
- 1-(2-chloroethyl)-1-nitroso-3-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methyl]urea
- SMILES
- CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CNC(=O)N(CCCl)N=O)O)O)O
- InChIKey
- AHHFEZNOXOZZQA-ZEBDFXRSSA-N
- XLogP
- -1.7
- Polar surface area
- 141 Ų
- H-bond donors
- 4
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- neoplasm, adult T-cell leukemia/lymphoma
via ChEMBL · EBI
Research
233 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 327.083
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₀H₁₈ClN₃O₇
- isomeric SMILES
- CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CNC(=O)N(CCCl)N=O)O)O)O
- canonical SMILES
- COC1C(C(C(C(O1)CNC(=O)N(CCCl)N=O)O)O)O
- subject has role
- antineoplastic
- Commons category
- Ranimustine
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- References
- External links
{{Drugbox | verifiedrevid = 448120715 | IUPAC_name = Methyl 6-({[(2-chloroethyl)(nitroso)amino]carbonyl}amino)-6-deoxy-α-D-glucopyranoside | image = Ranimustine (Haworth).svg | image_class = skin-invert-image | width = 215
| tradename = Cymerin | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = IV
Excerpted from Wikipedia’s “ranimustine” article, available under the CC BY-SA 4.0 licence.