MLST8
Sign in to saveAlso known as GBL, GbetaL, LST8, POP3, WAT1, MTOR associated protein, LST8 homolog
Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene. It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals. It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.
Gene data
MLST8- Name
- MTOR associated protein MLST8
- Type
- protein-coding
- Position
- 2,204,248–2,209,453 (+)
- Aliases
- GBL, GbetaL, LST8, POP3, WAT1
- Ensembl
- ENSG00000167965
- RefSeq RNA
- NM_001199173.3, NM_001199174.3, NM_001199175.3, NM_001352057.2, NM_001352059.2
- RefSeq protein
- NP_001186102.1, NP_001186103.1, NP_001186104.1, NP_001338986.1, NP_001338988.1
Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 6833
- exact match
- identifiers.org/ncbigene/64223
- genomic start
- 2254249
- genomic end
- 2209453
- cytogenetic location
- 16p13.3
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene. It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals. It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.
==References==