MMP12

Also known as HME, ME, MME, MMP-12, Matrix metallopeptidase 12

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 148 inbound references to MMP12, and connects out to Q180686, Q229883 and human chromosome 11.

It sits within the topics EC 3.4.24, Genes on human chromosome 11 and Human proteins.

Vinony links it to 4 Wikipedia language editions.

Gene data

MMP12

Name: matrix metallopeptidase 12
Type: protein-coding
Position: 102,862,734–102,874,990 (−)
Aliases: HME, ME, MME, MMP-12
Ensembl: ENSG00000262406
RefSeq RNA: NM_002426.6
RefSeq protein: NP_002417.2

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016].