MMP14

Name

matrix metallopeptidase 14

Type

protein-coding

Position

22,836,532–22,849,041 (+)

Aliases

MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS

Ensembl

ENSG00000157227

RefSeq RNA

NM_004995.4

RefSeq protein

NP_004986.1

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

matrix metallopeptidase 14

Symbol

MMP14

Biotype

Protein coding

Organism

Homo sapiens

Location

14:22,836,532-22,849,041

Strand

Forward (+)

Assembly

GRCh38

Protein · UniProt

Matrix metalloproteinase-14

Gene

Mmp14

Organism

Rattus norvegicus (Rat)

Length

582 aa

Molecular mass

66,080 Da

Evidence

2: Evidence at transcript level

Endopeptidase that degrades various components of the extracellular matrix such as collagen (By similarity). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleave…

Wikidata facts

Instance of

protein

Image

Protein MMP14 PDB 1bqq.png

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