MMS22L

Also known as C6orf167, dJ39B17.2, MMS22 like, DNA repair protein

Methyl methanesulfonate-sensitivity protein 22-like also known as MMS22-like, DNA repair protein is a protein that in humans is encoded by the MMS22L gene.

In the Vinony graph

Within Vinony's link graph, MMS22L is referenced by 1 other article, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

It is catalogued under topics including Genes mutated in mice and Genes on human chromosome 6.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MMS22L

Name: MMS22 like, DNA repair protein
Type: protein-coding
Position: 97,141,741–97,283,241 (−)
Aliases: C6orf167, dJ39B17.2
Ensembl: ENSG00000146263
RefSeq RNA: NM_001350599.2, NM_001350600.2, NM_198468.4, XM_006715432.4, XM_011535670.3
RefSeq protein: NP_001337528.1, NP_001337529.1, NP_940870.2, XP_006715495.1, XP_011533972.1

The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017].

Gene Ontology

Biological process

double-strand break repair via homologous recombination double-strand break repair via homologous recombination double-strand break repair via homologous recombination double-strand break repair via homologous recombination replication fork processing replication fork processing replication fork processing replication fork processing

Molecular function

single-stranded DNA binding protein binding

Cellular component

nucleus nucleus nucleus nucleoplasm chromosome chromosome FACT complex site of double-strand break

via MyGene.info

Gene · Ensembl

MMS22 like, DNA repair protein

Symbol: MMS22L
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:97,141,741-97,283,241
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 18874
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/253714
genomic end: 97731093
genomic start: 97590037
chromosome: human chromosome 6
cytogenetic location: 6q16.1
expressed in: Achilles tendon

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Methyl methanesulfonate-sensitivity protein 22-like also known as MMS22-like, DNA repair protein is a protein that in humans is encoded by the MMS22L gene.

== References ==

Excerpted from Wikipedia’s “MMS22L” article, available under the CC BY-SA 4.0 licence.