MAML2
Sign in to saveAlso known as MAM-3, MAM2, MAM3, MLL-MAML2, mastermind like transcriptional coactivator 2
Mastermind-like protein 2 is a protein that in humans is encoded by the MAML2 gene.
In the Vinony graph
Vinony's link graph records 7 inbound references to MAML2, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Vinony links it to 6 Wikipedia language editions.
Gene data
MAML2- Name
- mastermind like transcriptional coactivator 2
- Type
- protein-coding
- Position
- 95,976,598–96,343,255 (−)
- Aliases
- MAM-3, MAM2, MAM3, MLL-MAML2
- Ensembl
- ENSG00000184384
- RefSeq RNA
- NM_032427.4, XM_011543023.4, XM_047427710.1, XM_054370189.1
- RefSeq protein
- NP_115803.1, XP_011541325.1, XP_047283666.1, XP_054226164.1
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
mastermind like transcriptional coactivator 2
- Symbol
- MAML2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:95,976,598-96,343,255
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/84441
- genomic end
- 96343195
- genomic start
- 95709762
- chromosome
- human chromosome 11
- cytogenetic location
- 11q21
- expressed in
- synovial membrane
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
Mastermind-like protein 2 is a protein that in humans is encoded by the MAML2 gene.
== See also ==
Excerpted from Wikipedia’s “MAML2” article, available under the CC BY-SA 4.0 licence.