DCLRE1A

Also known as PSO2, SNM1, SNM1A, DNA cross-link repair 1A

DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.

In the Vinony graph

Within Vinony's link graph, DCLRE1A is referenced by 3 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 10.

Its subject is documented across 5 Wikipedia language editions.

Gene data

DCLRE1A

Name: DNA cross-link repair 1A
Type: protein-coding
Position: 113,834,725–113,854,417 (−)
Aliases: PSO2, SNM1, SNM1A
Ensembl: ENSG00000198924
RefSeq RNA: NM_001271816.2, NM_014881.5, XM_006718090.2, XM_011540429.2, XM_054367336.1
RefSeq protein: NP_001258745.1, NP_055696.3, XP_006718153.1, XP_011538731.1, XP_054223311.1

This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

Gene Ontology

Biological process

DNA repair double-strand break repair via nonhomologous end joining interstrand cross-link repair

Molecular function

DNA binding damaged DNA binding beta-lactamase activity beta-lactamase activity 5'-3' DNA exonuclease activity 5'-3' DNA exonuclease activity

Cellular component

nucleus nucleus nucleoplasm nucleoplasm

Pathways

Fanconi Anemia Pathway DNA Repair

via MyGene.info

Gene · Ensembl

DNA cross-link repair 1A

Symbol: DCLRE1A
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:113,834,725-113,854,417
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 8920
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9937
genomic end: 115614142
genomic start: 115594488
chromosome: human chromosome 10
cytogenetic location: 10q25.3

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Function
References
Further reading

DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM] ==Function==

Excerpted from Wikipedia’s “DCLRE1A” article, available under the CC BY-SA 4.0 licence.