DCLRE1A

Also known as PSO2, SNM1, SNM1A, DNA cross-link repair 1A

DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.

Gene data

DCLRE1A

Name: DNA cross-link repair 1A
Type: protein-coding
Aliases: PSO2, SNM1, SNM1A

This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

via MyGene.info

Gene · Ensembl

DNA cross-link repair 1A

Symbol: DCLRE1A
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:113,834,725-113,854,417
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8920
exact match: identifiers.org/ncbigene/9937
genomic end: 115614142
genomic start: 115594488
cytogenetic location: 10q25.3

Sources (3)

via Wikidata · CC0

~1 min read

Article

3 sections

Contents

Function
References
Further reading

DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM] ==Function==