MTHFD2

Also known as NMDMC, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

gene umano

In the Vinony graph

Within Vinony's link graph, MTHFD2 is referenced by 4 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MTHFD2

Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Type: protein-coding
Position: 74,186,172–74,218,432 (+)
Aliases: NMDMC
Ensembl: ENSG00000065911
RefSeq RNA: NM_001410192.1, NM_006636.4, XM_006711924.3, XM_054340222.1
RefSeq protein: NP_001397121.1, NP_006627.2, XP_006711987.1, XP_054196197.1

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009].