MTNR1B
Sign in to saveAlso known as FGQTL2, MEL-1B-R, MT2, Melatonin receptor 1B
protein-coding gene in the species Homo sapiens
Gene data
MTNR1B- Name
- melatonin receptor 1B
- Type
- protein-coding
- Position
- 92,969,651–92,985,066 (+)
- Aliases
- FGQTL2, MEL-1B-R, MT2
- Ensembl
- ENSG00000134640
- RefSeq RNA
- NM_005959.5, XM_011542839.3, XM_017017777.2, XM_054368848.1, XM_054368849.1
- RefSeq protein
- NP_005950.1, XP_011541141.1, XP_016873266.1, XP_054224823.1, XP_054224824.1
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
G protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerchemical synaptic transmissionnegative regulation of receptor guanylyl cyclase signaling pathwayglucose homeostasispositive regulation of circadian rhythm
Molecular function
Cellular component
Pathways
Neuroactive ligand-receptor interaction - Homo sapiens (human)Circadian entrainment - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)GPCR downstream signallingG alpha (i) signalling eventsGPCR ligand bindingSmall Ligand GPCRsMelatonin metabolism and effects
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4350
- exact match
- identifiers.org/ncbigene/4544
- genomic end
- 92718232
- genomic start
- 92969651
- cytogenetic location
- 11q14.3
via Wikidata · CC0
Connections
Q180686
Entity
G protein-coupled recepteishon
Entity
Ensembl genome database project
Entity
cell surface receptor
Entity
MTNR1A
Gene
brain
Entity
protein
Entity
Wikidata
Entity
gene
Entity
chromosome
Entity
public domain
Entity
digital object identifier
Entity
retina
Entity
melatonin
Entity
pheromone
Entity
pineal gland
Entity
bibcode
Entity
blood glucose
Entity
type 2 diabetes
Disease
human genome
Entity