MYCN

Also known as MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

Gene data

MYCN

Name: MYCN proto-oncogene, bHLH transcription factor
Type: protein-coding
Position: 15,938,396–15,947,022 (+)
Aliases: FGLDS1, MODED, MPAPA, MYCNsORF, MYCNsPEP, N-myc, NMYC, ODED, bHLHe37
Ensembl: ENSG00000134323
RefSeq RNA: NM_001293228.2, NM_001293231.2, NM_001293233.2, NM_001446166.1, NM_005378.6
RefSeq protein: NP_001280157.1, NP_001280160.1, NP_001280162.1, NP_001433095.1, NP_005369.2

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of gene expression negative regulation of gene expression positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nucleus nucleoplasm

Pathways

Transcriptional misregulation in cancer - Homo sapiens (human)Adaptive Immune System Cell-Cell communication Signal Transduction Immune System Signaling by ALK Regulation of T cell activation by CD28 family Co-inhibition by PD-1 Adherens junctions interactions Cell-cell junction organization

via MyGene.info

Gene · Ensembl

MYCN proto-oncogene, bHLH transcription factor

Symbol: MYCN
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:15,938,396-15,947,022
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: MYCN structure.png

Show 7 more facts

HomoloGene ID: 3922
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4613
genomic end: 16087129
genomic start: 15940550
chromosome: human chromosome 2
cytogenetic location: 2p24.3

Sources (6)

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Encyclopedic overview

7 sections

Contents

Function
Clinical significance
Interactions
See also
References
Further reading
External links

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

== Function ==

Excerpted from Wikipedia’s “MYCN” article, available under the CC BY-SA 4.0 licence.

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MYCN

Gene data

Gene Ontology

Pathways

Gene · Ensembl

Wikidata facts

Encyclopedic overview

Available in 7 languages

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