N,N-diisopropylethylamine
'''N,N-Diisopropylethylamine, or Hünig's base, is an organic compound that is a tertiary amine. It is named after the German chemist . It is used in organic chemistry as a non-nucleophilic base. It is commonly abbreviated as DIPEA, DIEA, or i-Pr2NEt'''.
Article
10 sectionsContents
- Structure
- Occurrence and preparation
- Uses and reactions
- Amide coupling
- Alkylations
- Transition metal catalyzed cross-coupling reactions
- Swern oxidation
- Examples of DIPEA used as a substrate
- Comparison with triethylamine
- References
'''N,N-Diisopropylethylamine, or Hünig's base, is an organic compound that is a tertiary amine. It is named after the German chemist . It is used in organic chemistry as a non-nucleophilic base. It is commonly abbreviated as DIPEA, DIEA, or i-Pr2NEt'''.
== Structure == DIPEA consists of a central nitrogen atom that is bonded to an ethyl group and two isopropyl groups. A lone pair of electrons resides on the nitrogen atom, which can react with electrophiles. However, the three alkyl groups on the nitrogen atom create steric hindrance, so only small electrophiles such as protons can react with the nitrogen lone pair.