NAA80

Also known as FUS-2, FUS2, N-acetyltransferase 6, NAT6, N(alpha)-acetyltransferase 80, NatH catalytic subunit, HsNAAA80, N-alpha-acetyltransferase 80, NatH catalytic subunit

thumb|alt=|320x320px|Crystal structure of [[Drosophila melanogaster Naa80. Substrate peptide is shown as yellow sticks and CoA is shown as cyan sticks. Enzyme is displayed as cyan cartoon. (PDB ID: 5WJE)]]N-acetyltransferase 80 (also known as NAT6 or FUS2) is a protein that in humans is encoded by the NAA80 gene. It acetylates the N-terminus of mature actin.

Gene data

NAA80

Name: N-alpha-acetyltransferase 80, NatH catalytic subunit
Type: protein-coding
Aliases: ANDS, FUS-2, FUS2, HsNAAA80, NAT6

This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011].

via MyGene.info