NAE1
Sign in to saveAlso known as A-116A10.1, APPBP1, ula-1, HPP1, NEDD8 activating enzyme E1 subunit 1
NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.
Gene data
NAE1- Name
- NEDD8 activating enzyme E1 subunit 1
- Type
- protein-coding
- Aliases
- A-116A10.1, APPBP1, HPP1, NEDFIH, ula-1
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
NEDD8 activating enzyme E1 subunit 1
- Symbol
- NAE1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:66,802,874-66,873,256
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein APPBP1 PDB 1r4m.png
Show 5 more facts
- HomoloGene ID
- 68370
- exact match
- identifiers.org/ncbigene/8883
- genomic end
- 66907159
- genomic start
- 66836778
- cytogenetic location
- 16q22.1
Sources (4)
via Wikidata · CC0
~7 min read
Article
10 sectionsContents
- Function
- History
- Role in NEDD8 activation
- Role in DNA repair
- Role in cancer therapy
- Clinical trials
- Interactions
- References
- Further reading
- External links
NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.
== Function ==