Structure via PubChem · Public domain (PubChem)
naftifine
Sign in to saveAlso known as Naftin, Naftifin, Naftifina, Naftifinum, trans-N-cinnamyl-N-methyl-(1-naphthylmethyl)amine, (E)-N-cinnamyl-N-methyl-1-naphthalenemethylamine
Naftifine hydrochloride (brand names include Exoderil and Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (topical fungal infections).
Chemical data
- Formula
- C21H21N
- Molecular weight
- 287.4 g/mol
- IUPAC name
- (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
- SMILES
- CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32
- InChIKey
- OZGNYLLQHRPOBR-DHZHZOJOSA-N
- XLogP
- 5.1
- Polar surface area
- 3.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1988
- Admin. routes
- topical
- Indications
- tinea pedis, tinea unguium
via ChEMBL · EBI
Research
237 papers- Naftifine.2006
- Naftifine: a review.Journal of cutaneous medicine and surgery · 2008
- Naftifine: A Topical Allylamine for Superficial Dermatophytosis.The Journal of the Association of Physicians of India · 2023
- Naftifine Hydrochloride Gel 2%: An Effective Topical Treatment for Moccasin-Type Tinea Pedis.Journal of drugs in dermatology : JDD · 2015
- Potential of Naftifine Application for Transungual Delivery.Molecules (Basel, Switzerland) · 2020
via PubMed
Wikidata facts
- Has part
- hydrogen
- Mass
- 287.167
- Has use
- medication
Show 7 more facts
- Commons category
- Naftifine
- medical condition treated
- tinea pedis
- chemical formula
- C₂₁H₂₁N
- canonical SMILES
- CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32
- isomeric SMILES
- CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32
- World Health Organisation international non-proprietary name
- naftifine
- subject has role
- antifungal
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Naftifine hydrochloride (brand names include Exoderil and Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (topical fungal infections).
Naftifine was invented at the Sandoz Research Institute in Vienna, Austria. It was the first successful antifungal medication of the allylamine class.
Excerpted from Wikipedia’s “naftifine” article, available under the CC BY-SA 4.0 licence.