NECAB3

Also known as APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to NECAB3, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 20.

Vinony links it to 5 Wikipedia language editions.

Gene data

NECAB3

Name: N-terminal EF-hand calcium binding protein 3
Type: protein-coding
Position: 33,657,087–33,674,473 (−)
Aliases: APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5
Ensembl: ENSG00000125967
RefSeq RNA: NM_031231.4, NM_031232.4, XM_005260510.1, XM_011528991.2, XM_011528992.3
RefSeq protein: NP_112508.3, NP_112509.3, XP_005260567.1, XP_011527293.1, XP_011527294.1

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

protein secretion protein metabolic process regulation of amyloid precursor protein biosynthetic process regulation of amyloid precursor protein biosynthetic process

Molecular function

calcium ion binding protein binding

Cellular component

Golgi cis cisterna Golgi cis cisterna Golgi cis cisterna nucleus cytoplasm cytoplasm endoplasmic reticulum endoplasmic reticulum

via MyGene.info

Gene · Ensembl

N-terminal EF-hand calcium binding protein 3

Symbol: NECAB3
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:33,657,087-33,674,473
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 10992
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/63941
genomic end: 32262269
genomic start: 32244893
chromosome: human chromosome 20
cytogenetic location: 20q11.22

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

See also
References
External links
Further reading

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.

The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.

Excerpted from Wikipedia’s “NECAB3” article, available under the CC BY-SA 4.0 licence.