niacinamide
Sign in to saveNicotinamide (INN, BAN ) or niacinamide (USAN ) (IUPAC name: 3-pyridinecarboxoamide) is a form of vitamin B3 found in food and used as a dietary supplement and medication. As a supplement, it is used orally (swallowed by mouth) to prevent and treat pellagra (niacin deficiency). This is not to be confused with Niacin. While both are very similar both have different behaviors on the body. While nicotinic acid (niacin) may be used for this purpose, nicotinamide has the benefit of not causing skin flushing. As a cream, it is used to treat acne, and has been observed in clinical studies to improve
Key facts
- Drug.image
- Nicotinamid.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Nicotinamide-from-xtal-2011-Mercury-3D-sf.png
- Drug.image_class2
- bg-transparent
- Drug.pronounce
- ,
- Drug.DailyMedID
- Niacinamide
- Drug.routes_of_administration
- oral, topical
- Drug.ATC_prefix
- A11
- Drug.ATC_suffix
- HA01
- Drug.legal_US
- OTC
- Drug.CAS_number
- 98-92-0
- Drug.PubChem
- 936
- Drug.DrugBank
- DB02701
- Drug.ChemSpiderID
- 911
- Drug.UNII
- 25X51I8RD4
- Drug.KEGG
- D00036
- Drug.ChEBI
- 17154
- Drug.ChEMBL
- 1140
via Wikipedia infobox
Research
19,665 papers- Niacinamide - mechanisms of action and its topical use in dermatology.Skin pharmacology and physiology · 2014
- Niacinamide: a review on dermal delivery strategies and clinical evidence.Drug delivery and translational research · 2024
- Cosmeceutical Aptitudes of Niacinamide: A Review.Recent advances in anti-infective drug discovery · 2021
- The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.The British journal of dermatology · 2002
- Final report of the safety assessment of niacinamide and niacin.International journal of toxicology · 2005
via PubMed
Article
15 sectionsContents
- Medical uses
- Niacin deficiency
- Acne
- Skin cancer
- Eye health
- Side effects
- Chemistry
- Industrial production
- Biochemistry
- Biological role
- Food sources
- Compendial status
- Research
- Extra-terrestrial occurrence
- References
Nicotinamide (INN, BAN ) or niacinamide (USAN ) (IUPAC name: 3-pyridinecarboxoamide) is a form of vitamin B3 found in food and used as a dietary supplement and medication. As a supplement, it is used orally (swallowed by mouth) to prevent and treat pellagra (niacin deficiency). This is not to be confused with Niacin. While both are very similar both have different behaviors on the body. While nicotinic acid (niacin) may be used for this purpose, nicotinamide has the benefit of not causing skin flushing. As a cream, it is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness. It is a water-soluble vitamin.
Clinical trials have show promise in eye health, in this B3 form, it has shown promise in protecting eye health, particularly in the context of glaucoma. It is believed to support the health of retinal ganglion cells and may help protect against the damage caused by glaucoma. Nicotinamide has been studied for its potential neuroprotective effects, and while some clinical trials have demonstrated improvements in visual fields and retinal function, it is not yet approved for the treatment of glaucoma. The use of nicotinamide should be approached with caution, especially at high doses, due to the risk of liver injury. Ongoing research continues to explore the full potential of nicotinamide in eye protection and its role in managing eye conditions.